Russian Vaccine produces anti-bodies in every participant and has no serious side effects

[Lemoentjie]

The results of the two trials, conducted in June-July this year and involving 76 participants, showed 100% of participants developing antibodies to the new coronavirus and no serious side effects, The Lancet said.

Russia licensed the two-shot jab for domestic use in August, the first country to do so and before any data had been published or a large-scale trial begun.

“The two 42-day trials – including 38 healthy adults each – did not find any serious adverse effects among participants, and confirmed that the vaccine candidates elicit an antibody response,” The Lancet said.

https://www.reuters.com/article/us-heal ... SKBN25V1I2

Well done to Russia

[Kawazaki]

They are going to do a further trial in Shrewsbury apparently.

[Saint]

The results of the two trials, conducted in June-July this year and involving 76 participants, showed 100% of participants developing antibodies to the new coronavirus and no serious side effects, The Lancet said.

Russia licensed the two-shot jab for domestic use in August, the first country to do so and before any data had been published or a large-scale trial begun.

“The two 42-day trials – including 38 healthy adults each – did not find any serious adverse effects among participants, and confirmed that the vaccine candidates elicit an antibody response,” The Lancet said.

https://www.reuters.com/article/us-heal ... SKBN25V1I2

Well done to Russia

Congrats yo Russia. They've completed something between Phase I and Phase II. Phase I confirms safety, Phase II confirms response, but realistically they should have more candidates for it to go confirmed. No mention of T-Cell response.

In context, the Oxford vaccine candidate reached this point several months ago with a larger Phase Ii. 3 other vaccine candidates have also reached this point inside the last month.

So welk done Russia, but let's keep ro some basic approval protocols?

[A6D6E6]

The results of the two trials, conducted in June-July this year and involving 76 participants, showed 100% of participants developing antibodies to the new coronavirus and no serious side effects, The Lancet said.

Russia licensed the two-shot jab for domestic use in August, the first country to do so and before any data had been published or a large-scale trial begun.

“The two 42-day trials – including 38 healthy adults each – did not find any serious adverse effects among participants, and confirmed that the vaccine candidates elicit an antibody response,” The Lancet said.

https://www.reuters.com/article/us-heal ... SKBN25V1I2

Well done to Russia

Congrats yo Russia. They've completed something between Phase I and Phase II. Phase I confirms safety, Phase II confirms response, but realistically they should have more candidates for it to go confirmed. No mention of T-Cell response.

In context, the Oxford vaccine candidate reached this point several months ago with a larger Phase Ii. 3 other vaccine candidates have also reached this point inside the last month.

So welk done Russia, but let's keep ro some basic approval protocols?

He won't be able to reply until he takes Putin's cock out of his mouth.

[The Druid]

The results of the two trials, conducted in June-July this year and involving 76 participants, showed 100% of participants developing antibodies to the new coronavirus and no serious side effects, The Lancet said.

Russia licensed the two-shot jab for domestic use in August, the first country to do so and before any data had been published or a large-scale trial begun.

“The two 42-day trials – including 38 healthy adults each – did not find any serious adverse effects among participants, and confirmed that the vaccine candidates elicit an antibody response,” The Lancet said.

https://www.reuters.com/article/us-heal ... SKBN25V1I2


No side effects you say?











Well done to Russia

[Biffer]

So they’ve got to phase I/II. Good.

Let me know how full phase II and phase III go. Should be complete by the tail end of next year. Then those full results can be presented for licensing approvals.

[stemoc]

the irony is that its easy to make a vaccine using anti-bodies but people who have the power to make them want more money to do it....greed is what's ensuring the vaccine takes time and the more ppl die, the better it is for these companies cause the more they will get paid to release them, good on Russia, china already has a vaccine and has been administering it for months now and America has been fighting with its own citizens the last 3 months that they didn't even notice..

[Raggs]

the irony is that its easy to make a vaccine using anti-bodies but people who have the power to make them want more money to do it....greed is what's ensuring the vaccine takes time and the more ppl die, the better it is for these companies cause the more they will get paid to release them, good on Russia, china already has a vaccine and has been administering it for months now and America has been fighting with its own citizens the last 3 months that they didn't even notice..

I'll admit it's been a while since I've studied this stuff in depth, but could you tell me how you make a vaccine using anti-bodies?

What if there's a side effect that only effects 1 in 500 people? 78 tested is very unlikely to show that, but if you give it to millions you'll see it.

What if the anti-body response is very good to the vaccine, but not actually that useful against the virus? Or worse, actually make it worse?

Long term, large scale trials, including exposing vaccinated volunteers, are essential.

[Biffer]

the irony is that its easy to make a vaccine using anti-bodies but people who have the power to make them want more money to do it....greed is what's ensuring the vaccine takes time and the more ppl die, the better it is for these companies cause the more they will get paid to release them, good on Russia, china already has a vaccine and has been administering it for months now and America has been fighting with its own citizens the last 3 months that they didn't even notice..

Poor understanding on every level in this.

[Biffer]

Let's be clear here, this is the sixth or seventh vaccine candidate to show this response. Multiple different vaccine techniques being used. Any medical treatment can have adverse effects at rates of one in 100 or 1,000 or 10,000, which is why wider trials are required. This idea that some people, who are frankly uninformed fucking halfwits, have that it's being delayed and taking a long time is some of the most stupid, uneducated bullshit I've ever seen. These vaccine programmes are already being massively accelerated but certain fucktards on these threads seem to think they understand it better because they've read some extremist propaganda somewhere and consider that to be their 'research'. Even if they're deliberately trolling to get a reaction, it's the kind of moronic contribution that contributes to a broader conspiracy theory atmosphere which, in the end will kill people. And you guys share that responsibility. You're cunts.

[Fangle]

CDC have told the US states to be prepared for a large vaccine roll out at the beginning of November. Presumably that is when the final stages of phase 3 testing is complete.

[Biffer]

CDC have told the US states to be prepared for a large vaccine roll out at the beginning of November. Presumably that is when the final stages of phase 3 testing is complete.

Nope. They’re cutting the phase 3 short, it’s incredibly reckless because the technique being used by the modern a vaccine has never been used to develop a vaccine before. Who knows what unexpected effects it might have, or what it’s long term efficacy might be.

[Raggs]

CDC have told the US states to be prepared for a large vaccine roll out at the beginning of November. Presumably that is when the final stages of phase 3 testing is complete.

Nope. They’re cutting the phase 3 short, it’s incredibly reckless because the technique being used by the modern a vaccine has never been used to develop a vaccine before. Who knows what unexpected effects it might have, or what it’s long term efficacy might be.

Think they're actually relying on phase 3 results from other countries, whereas typically they'd have had their own.

Brazil phase 3 must have been going on for a fair while by now, think it was estimated for Oct?

[Biffer]

CDC have told the US states to be prepared for a large vaccine roll out at the beginning of November. Presumably that is when the final stages of phase 3 testing is complete.

Nope. They’re cutting the phase 3 short, it’s incredibly reckless because the technique being used by the modern a vaccine has never been used to develop a vaccine before. Who knows what unexpected effects it might have, or what it’s long term efficacy might be.

Think they're actually relying on phase 3 results from other countries, whereas typically they'd have had their own.

Brazil phase 3 must have been going on for a fair while by now, think it was estimated for Oct?

No. It’s a different vaccine, so the results of tests from other vaccines are entirely meaningless.

Phase 3 for the Oxford vaccine lasts until about August next year, there won’t be results until then. None of the phase 3 trials are due to complete until the middle of next year.

[Sandstorm]

American vaccine will be ready about a week before the election.

[Saint]

Nope. They’re cutting the phase 3 short, it’s incredibly reckless because the technique being used by the modern a vaccine has never been used to develop a vaccine before. Who knows what unexpected effects it might have, or what it’s long term efficacy might be.

Think they're actually relying on phase 3 results from other countries, whereas typically they'd have had their own.

Brazil phase 3 must have been going on for a fair while by now, think it was estimated for Oct?

No. It’s a different vaccine, so the results of tests from other vaccines are entirely meaningless.

Phase 3 for the Oxford vaccine lasts until about August next year, there won’t be results until then. None of the phase 3 trials are due to complete until the middle of next year.

That it entirely accurate. Phase III of a vaccine test effectively lasts up till the point where you have significant evidence one way or the other as to it's effectiveness. This us a major reason why the Oxford vaccine isn't just being trialled in the UK at this stage, as there isn't now enough COVID in the UK to rapidly build up the data needed.

They're hoping that they will have enough data proving it works by late October/early November. That then needs to be peer reviewed before anything goes any further.

Note that "works" for a vaccine doesn't mean 100% effective. Realistically, a vaccine will be signed off if it is somewhere between 60 and 70 percent effective.

The NHS is definitely gearing up for a late November inoculation effort. Mrs Saint us being told to plan flu vaccinations to be completed by the end of 1st week of November, which is around a month ahead of the usual schedule

[Niegs]

The way this year's been going, I'm putting a bet on the vaccine having nanotech and we'll turn into bots for the Federation.

[Sandstorm]

A massive flu vaccine push is dumb. Everyone is keeping away from everyone else, wearing masks and washing their hands like mad. How the hell are you going to get flu???

BTW NHS and Private GP surgeries are getting a bonus this year for giving out more flu vaccines.....

[EnergiseR]

American vaccine will be ready about a week before the election.

Cut to

[Raggs]

A massive flu vaccine push is dumb. Everyone is keeping away from everyone else, wearing masks and washing their hands like mad. How the hell are you going to get flu???

BTW NHS and Private GP surgeries are getting a bonus this year for giving out more flu vaccines.....

You'll get it the same way as usual, especially if there's been a vaccine for covid, which will lead to some huge crowds of people being silly.

[Ted.]

American vaccine will be ready about a week before the election.

Absolutely guaranteed.

[Fangle]

American vaccine will be ready about a week before the election.

Absolutely guaranteed.

On TV the other day doctors were saying that not enough testing has been on ‘persons of color’, so it looks as if it will only be released in mid November at the earliest.

[Steve]

I wont be first in the queue for this or any other vaccine. Has there ever been one this rushed?


Im no anti vaxxer but im old enough to remember the children of thalidomide as Billy Joel called them .

[Saint]

The Western vaccines are going through effectively the same processes that a regular vaccine does. What's changed is that some stages are being run concurrently; in the case of the Oxford vaccine a lot of work on MERS was able to be repurposed saving a lot of development work; in the US they're using a completely new development "platform " for the first time in anger (it's gone through a lot of testing already)

A few tears ago this type of accelerated vaccine development simply wouldn't have been possible, but we're effectively at a tipping point for this type of medical research.

By the time any Western vaccines is made widly available, it will have been tested on 30,000 to 50,000 people already - and the core technologies will have been tested on millions of people over the last 5 years or so

[Biffer]

The Western vaccines are going through effectively the same processes that a regular vaccine does. What's changed is that some stages are being run concurrently; in the case of the Oxford vaccine a lot of work on MERS was able to be repurposed saving a lot of development work; in the US they're using a completely new development "platform " for the first time in anger (it's gone through a lot of testing already)

A few tears ago this type of accelerated vaccine development simply wouldn't have been possible, but we're effectively at a tipping point for this type of medical research.

By the time any Western vaccines is made widly available, it will have been tested on 30,000 to 50,000 people already - and the core technologies will have been tested on millions of people over the last 5 years or so

The key thing that has been omitted though is the long term effects, obviously. Well have no idea what the effect of this vaccine is after twelve or eighteen months. I think that’s a particular worry for the American one as it’s a new technique.

[Saint]

The Western vaccines are going through effectively the same processes that a regular vaccine does. What's changed is that some stages are being run concurrently; in the case of the Oxford vaccine a lot of work on MERS was able to be repurposed saving a lot of development work; in the US they're using a completely new development "platform " for the first time in anger (it's gone through a lot of testing already)

A few tears ago this type of accelerated vaccine development simply wouldn't have been possible, but we're effectively at a tipping point for this type of medical research.

By the time any Western vaccines is made widly available, it will have been tested on 30,000 to 50,000 people already - and the core technologies will have been tested on millions of people over the last 5 years or so

The key thing that has been omitted though is the long term effects, obviously. Well have no idea what the effect of this vaccine is after twelve or eighteen months. I think that’s a particular worry for the American one as it’s a new technique.

True long term effects of any vaccine aren't discovered during the current process.

Realistically, there needs to be some perspective in where the risks actually lie and what they are. The real risk of a vaccine is that rather than immunise, it accelerates the effects of the virus - which is why one ifbthe early tests in animals is to overexpose them.

These are not drugs and cannot be compared to thalidomide. If they don't act as a catalyst to the virus, and don't cause an illness directly themselves, they're inactive bodies that tge immune system either learns from, or ignores.

The vastly more likely scenario is that rather than be dangerous, it simply doesn't work - which is what Phasee III trials determine

[Lobby]

Looks like the Lancet has screwed up again

A group of prominent scientists and doctors has questioned the results of Russia’s research into a Covid-19 vaccine.

The group said there are a number of unexplained apparent duplications in Russia’s data — published in scientific journal The Lancet on Friday — concerning the antibody response of volunteers who took part in early stage trials of Russia's Sputnik V vaccine.

“There are very strange patterns in the data,” Enrico Bucci, a biology professor at Temple University in the U.S. who has published an open letter highlighting the concerns told The Moscow Times.

“By strange patterns I mean there are duplicate values for different [groups of] patients … which cannot be,” Bucci said, in reference to results concerning the production of antibodies by groups of patients who had been tested with different formulations of the vaccine.

Russia tested six different vaccine formulations on a total of 76 patients — four groups of nine and two groups of 20.

“Among the [different] groups of nine patients, testing completely different things, you see exactly the same numbers. It’s highly improbable to observe such a huge number of duplications,” Bucci said.

“It’s like if you throw a dice and you get exactly the same sequence of numbers several times — it’s highly improbable,” he added.

“The data looks like it's been photoshopped … it’s too similar and too unlikely from a statistical point of view,” Andrea Cossarizza, professor of pathology and immunology at the University of Modena and one of the signatories to the letter told The Moscow Times. He was referring to charts published along with the article in The Lancet.

Cossarizza went on to explain that it would be “very strange” for the same numbers to appear in all the possible experiments in different populations of people who received a vaccine.

Bucci said that published research into other vaccines currently being tested did not show such duplications.

“We looked into it and we didn’t discover anything strange with China’s vaccine, the U.S. vaccine or others like the Oxford vaccine. We didn’t find anything strange ... which is the usual situation.”

the scientists criticized the Russian authors and the journal for not publishing the full raw data alongside the study. Other published research into coronavirus vaccines has included original data which allows scientists around the world to scrutinize the results.

“I have no idea if [the results] could have been manipulated. We need to have access to the data. There might be an error, there might be an explanation, there might be fraud. We just don’t know. And this is not tolerable for such important research in such an important journal,” Bucci said.

Cossarizza said the results seem like such a clear error it is surprising they were not flagged before publication. “It could be a mistake,” he said, but added that in numerous other cases where an error of a similar scale has been published in a scientific paper, manipulation was at play.

https://www.themoscowtimes.com/2020/09 ... cet-a71384

[Raggs]

Noooo, really? Shock!

[MungoMan]

Looks like the Lancet has screwed up again

A group of prominent scientists and doctors has questioned the results of Russia’s research into a Covid-19 vaccine.

The group said there are a number of unexplained apparent duplications in Russia’s data — published in scientific journal The Lancet on Friday — concerning the antibody response of volunteers who took part in early stage trials of Russia's Sputnik V vaccine.

“There are very strange patterns in the data,” Enrico Bucci, a biology professor at Temple University in the U.S. who has published an open letter highlighting the concerns told The Moscow Times.

“By strange patterns I mean there are duplicate values for different [groups of] patients … which cannot be,” Bucci said, in reference to results concerning the production of antibodies by groups of patients who had been tested with different formulations of the vaccine.

Russia tested six different vaccine formulations on a total of 76 patients — four groups of nine and two groups of 20.

“Among the [different] groups of nine patients, testing completely different things, you see exactly the same numbers. It’s highly improbable to observe such a huge number of duplications,” Bucci said.

“It’s like if you throw a dice and you get exactly the same sequence of numbers several times — it’s highly improbable,” he added.

“The data looks like it's been photoshopped … it’s too similar and too unlikely from a statistical point of view,” Andrea Cossarizza, professor of pathology and immunology at the University of Modena and one of the signatories to the letter told The Moscow Times. He was referring to charts published along with the article in The Lancet.

Cossarizza went on to explain that it would be “very strange” for the same numbers to appear in all the possible experiments in different populations of people who received a vaccine.

Bucci said that published research into other vaccines currently being tested did not show such duplications.

“We looked into it and we didn’t discover anything strange with China’s vaccine, the U.S. vaccine or others like the Oxford vaccine. We didn’t find anything strange ... which is the usual situation.”

the scientists criticized the Russian authors and the journal for not publishing the full raw data alongside the study. Other published research into coronavirus vaccines has included original data which allows scientists around the world to scrutinize the results.

“I have no idea if [the results] could have been manipulated. We need to have access to the data. There might be an error, there might be an explanation, there might be fraud. We just don’t know. And this is not tolerable for such important research in such an important journal,” Bucci said.

Cossarizza said the results seem like such a clear error it is surprising they were not flagged before publication. “It could be a mistake,” he said, but added that in numerous other cases where an error of a similar scale has been published in a scientific paper, manipulation was at play.

https://www.themoscowtimes.com/2020/09 ... cet-a71384

The Lancet, like more than a few other UK institutions, seems hell-bent on pissing away an enviable and hard-won reputation.

Sad.

[Lemoentjie]

I see that the Astra Zeneca vaccine has been paused

[Raggs]

I see that the Astra Zeneca vaccine has been paused

Yep. It's what the larger scale trials are for, system working as it should. Rather than having to fake results in a trial with less than 100 people...

[Steve]

I wont be first in the queue for this or any other vaccine. Has there ever been one this rushed?


Im no anti vaxxer but im old enough to remember the children of thalidomide as Billy Joel called them .

https://www.irishtimes.com/business/hea ... -1.4350454


case in point.

[JM2K6]

I wont be first in the queue for this or any other vaccine. Has there ever been one this rushed?


Im no anti vaxxer but im old enough to remember the children of thalidomide as Billy Joel called them .

https://www.irishtimes.com/business/hea ... -1.4350454


case in point.

What is it you think that case proves? That's how proper vaccination trials operate.

[Steve]

I wont be first in the queue for this or any other vaccine. Has there ever been one this rushed?


Im no anti vaxxer but im old enough to remember the children of thalidomide as Billy Joel called them .

https://www.irishtimes.com/business/hea ... -1.4350454


case in point.

What is it you think that case proves? That's how proper vaccination trials operate.

That i was right to not want to be an early adopter of this vaccine. Thats why i quoted myself.

[Saint]

https://www.irishtimes.com/business/hea ... -1.4350454


case in point.

What is it you think that case proves? That's how proper vaccination trials operate.

That i was right to not want to be an early adopter of this vaccine. Thats why i quoted myself.

This is in trial stage. The reason they have trials is to catch possible issues. This is actually evidence that proper testing procedures are being followed to the letter

It's also totally unknown at this point if this was caused by the trial vaccine, or the control meningitis vaccine - or if it even had anything to do with the trials at all. As it's a blind study, only the independent assessor can review this to make the determination, which is the process that started today.

A so called "early adopter" will be someone taking the injection early AFTER the trials are completed and the vaccine is approved.

[Steve]

What is it you think that case proves? That's how proper vaccination trials operate.

That i was right to not want to be an early adopter of this vaccine. Thats why i quoted myself.

This is in trial stage. The reason they have trials is to catch possible issues. This is actually evidence that proper testing procedures are being followed to the letter

It's also totally unknown at this point if this was caused by the trial vaccine, or the control meningitis vaccine - or if it even had anything to do with the trials at all. As it's a blind study, only the independent assessor can review this to make the determination, which is the process that started today.

A so called "early adopter" will be someone taking the injection early AFTER the trials are completed and the vaccine is approved.

And ill be waiting for a good while after that before I join the queue for it. Thats all im saying.

[Saint]

That i was right to not want to be an early adopter of this vaccine. Thats why i quoted myself.

This is in trial stage. The reason they have trials is to catch possible issues. This is actually evidence that proper testing procedures are being followed to the letter

It's also totally unknown at this point if this was caused by the trial vaccine, or the control meningitis vaccine - or if it even had anything to do with the trials at all. As it's a blind study, only the independent assessor can review this to make the determination, which is the process that started today.

A so called "early adopter" will be someone taking the injection early AFTER the trials are completed and the vaccine is approved.

And ill be waiting for a good while after that before I join the queue for it. Thats all im saying.

Which has precisely nothing at all to do with the article you quoted, the pause in trials or anything. If you want to be the last person vaccinated then that's a choice you can make, but trying to justify it on the basis of today's reports is laughable.

[mat the expat]

And ill be waiting for a good while after that before I join the queue for it. Thats all im saying.

So you are an Anti-vaxxer?

[Ted.]

And ill be waiting for a good while after that before I join the queue for it. Thats all im saying.

So you are an Anti-vaxxer?

It would seem so. Or at least certainly not a team player.

[average joe]

I'll get vaccinated but I'll also wait a bit to see if any of yous that got it first don't turn into zombies.