NPR

Sandstorm wrote: ↑Mon Nov 16, 2020 8:56 pmABABBC

TB63 wrote: ↑Mon Nov 16, 2020 8:58 pm

Sandstorm wrote: ↑Mon Nov 16, 2020 8:56 pmABABBC

Bloody hell! Fantastic! Matched my answers exactly!

All wrong..

Sandstorm wrote: ↑Mon Nov 16, 2020 8:31 pm

Biffer wrote: ↑Mon Nov 16, 2020 7:50 pm

Longshanks wrote: ↑Mon Nov 16, 2020 4:50 pm Back in February many scientists were saying we were unlikely to see a successful covid vaccine
Today 4 are claiming they work and are safe, and that's without lots of others in development.
Maybe we'll also get a cure for the common cold out of this too.

Nah. That'd need vaccines for around 200 different viruses - that's why we don't have one, the common cold isn't one disease, it's a couple of hundred. And there's no financial return on developing a vaccine for a couple of percent of cases of the common cold.

Couple of cases? Common cold kills millions every week! It’s just like Covid19.

Niegs wrote: ↑Mon Nov 16, 2020 10:12 pm Feels equal parts infuriating and heartbreaking that people are so gaslit/defiant/ignorant, literally, until death believing it isn't real.

Bimbowomxn wrote: ↑Mon Nov 16, 2020 10:16 pm

Niegs wrote: ↑Mon Nov 16, 2020 10:12 pm Feels equal parts infuriating and heartbreaking that people are so gaslit/defiant/ignorant, literally, until death believing it isn't real.

Why link the Two events which clearly have nothing to do with current epidemic levels though?

Sandstorm wrote: ↑Mon Nov 16, 2020 10:42 pm

Bimbowomxn wrote: ↑Mon Nov 16, 2020 10:16 pm

Niegs wrote: ↑Mon Nov 16, 2020 10:12 pm Feels equal parts infuriating and heartbreaking that people are so gaslit/defiant/ignorant, literally, until death believing it isn't real.

Why link the Two events which clearly have nothing to do with current epidemic levels though?

It’s about their attitude to the virus, toolbag.

Sandstorm wrote: ↑Mon Nov 16, 2020 10:42 pm

Bimbowomxn wrote: ↑Mon Nov 16, 2020 10:16 pm

Niegs wrote: ↑Mon Nov 16, 2020 10:12 pm Feels equal parts infuriating and heartbreaking that people are so gaslit/defiant/ignorant, literally, until death believing it isn't real.

Why link the Two events which clearly have nothing to do with current epidemic levels though?

It’s about their attitude to the virus, toolbag.

Sandstorm wrote: ↑Mon Nov 16, 2020 8:31 pm

Biffer wrote: ↑Mon Nov 16, 2020 7:50 pm

Longshanks wrote: ↑Mon Nov 16, 2020 4:50 pm Back in February many scientists were saying we were unlikely to see a successful covid vaccine
Today 4 are claiming they work and are safe, and that's without lots of others in development.
Maybe we'll also get a cure for the common cold out of this too.

Nah. That'd need vaccines for around 200 different viruses - that's why we don't have one, the common cold isn't one disease, it's a couple of hundred. And there's no financial return on developing a vaccine for a couple of percent of cases of the common cold.

Couple of cases? Common cold kills millions every week! It’s just like Covid19.

Longshanks wrote: ↑Mon Nov 16, 2020 8:25 pm

Biffer wrote: ↑Mon Nov 16, 2020 7:50 pm

Longshanks wrote: ↑Mon Nov 16, 2020 4:50 pm Back in February many scientists were saying we were unlikely to see a successful covid vaccine
Today 4 are claiming they work and are safe, and that's without lots of others in development.
Maybe we'll also get a cure for the common cold out of this too.

Nah. That'd need vaccines for around 200 different viruses - that's why we don't have one, the common cold isn't one disease, it's a couple of hundred. And there's no financial return on developing a vaccine for a couple of percent of cases of the common cold.

Some of the therapeutics being developed i was referring to for the common cold
I realise I didn't make that clear

Bimbowomxn wrote: ↑Mon Nov 16, 2020 2:16 pm

Rhubarb & Custard wrote: ↑Mon Nov 16, 2020 2:15 pm

frodder wrote: ↑Mon Nov 16, 2020 1:36 pm

Through stability trialling throughout the development

And one assumes this isn't as such new technology

It’s the first vaccine of its type .... completely new technology.

mat the expat wrote: ↑Mon Nov 16, 2020 11:03 pm

Sandstorm wrote: ↑Mon Nov 16, 2020 10:42 pm

Bimbowomxn wrote: ↑Mon Nov 16, 2020 10:16 pm


Why link the Two events which clearly have nothing to do with current epidemic levels though?

It’s about their attitude to the virus, toolbag.

He really is the epitome of Chimps typing isn't he?

eldanielfire wrote: ↑Tue Nov 17, 2020 8:36 am

Bimbowomxn wrote: ↑Mon Nov 16, 2020 2:16 pm

Rhubarb & Custard wrote: ↑Mon Nov 16, 2020 2:15 pm

And one assumes this isn't as such new technology

It’s the first vaccine of its type .... completely new technology.

Nah it's not

Sandstorm wrote: ↑Mon Nov 16, 2020 10:42 pm

Bimbowomxn wrote: ↑Mon Nov 16, 2020 10:16 pm

Niegs wrote: ↑Mon Nov 16, 2020 10:12 pm Feels equal parts infuriating and heartbreaking that people are so gaslit/defiant/ignorant, literally, until death believing it isn't real.

Why link the Two events which clearly have nothing to do with current epidemic levels though?

It’s about their attitude to the virus, toolbag.

Bimbowomxn wrote: ↑Tue Nov 17, 2020 9:04 am

eldanielfire wrote: ↑Tue Nov 17, 2020 8:36 am

Bimbowomxn wrote: ↑Mon Nov 16, 2020 2:16 pm


It’s the first vaccine of its type .... completely new technology.

Nah it's not

I’ll ask you the same question what other RNA modification vaccine are humans currently or have ever taken ?

Bimbowomxn wrote: ↑Tue Nov 17, 2020 9:04 am

eldanielfire wrote: ↑Tue Nov 17, 2020 8:36 am

Bimbowomxn wrote: ↑Mon Nov 16, 2020 2:16 pm


It’s the first vaccine of its type .... completely new technology.

Nah it's not

I’ll ask you the same question what other RNA modification vaccine are humans currently or have ever taken ?

Rhubarb & Custard wrote: ↑Tue Nov 17, 2020 9:46 am

Bimbowomxn wrote: ↑Tue Nov 17, 2020 9:04 am

eldanielfire wrote: ↑Tue Nov 17, 2020 8:36 am

Nah it's not

I’ll ask you the same question what other RNA modification vaccine are humans currently or have ever taken ?

isn't this rather shifting the goalposts as this started with some speculating on how long a vaccine could be stored and retain usage? to which I noted it wasn't brand new tech, which it isn't in the sense there's decades of research into just this area now, and a great deal of effort has gone into being able to store vaccines at higher temps. The idea eventually would be to have vaccines, well anything in the mRNA field, being able to be stored outside the cold chain, but that's a ways off.

Bimbowomxn wrote: ↑Tue Nov 17, 2020 9:58 am

Rhubarb & Custard wrote: ↑Tue Nov 17, 2020 9:46 am

Bimbowomxn wrote: ↑Tue Nov 17, 2020 9:04 am



I’ll ask you the same question what other RNA modification vaccine are humans currently or have ever taken ?

isn't this rather shifting the goalposts as this started with some speculating on how long a vaccine could be stored and retain usage? to which I noted it wasn't brand new tech, which it isn't in the sense there's decades of research into just this area now, and a great deal of effort has gone into being able to store vaccines at higher temps. The idea eventually would be to have vaccines, well anything in the mRNA field, being able to be stored outside the cold chain, but that's a ways off.

A bit, however the tech has never been successfully applied and by accounts we are hearing very new tech has been used.

There a clear point this is the first vaccine if it’s type to be taken by humans not subject to testing.

Saint wrote: ↑Tue Nov 17, 2020 10:30 am I think some people are getting confused a bit about what an mRNA virus is/does.

It doesn't re-write your DNA
It doesn't introduce anything to your system that sticks around forever.
It doesn't use dangerous chemicals.
It's not active

It's simply a slightly different way of teaching the immune system how to fight a virus, with many potential benefits. The theory for this has been around since the 90s, but the kind technology required to manufacture this, particularly at scale, is only a couple of years old.

Not subject to testing? What do you think they've been doing for the last 7 months? This thing has been in trials since April. And the technology behind it is far far older. How then is it confusing to you that they know what temps it can be stored at safely for 6 months?

Bimbowomxn wrote: ↑Tue Nov 17, 2020 11:44 am

Not subject to testing? What do you think they've been doing for the last 7 months? This thing has been in trials since April. And the technology behind it is far far older. How then is it confusing to you that they know what temps it can be stored at safely for 6 months?

No one whom hasn’t been subject to testing has had the vaccine.

Oh, and they’ve not tested it for 7 months.

Oh and this process is normally years long and many more variants of test recipients.

Bimbowomxn wrote: ↑Tue Nov 17, 2020 11:44 am

Not subject to testing? What do you think they've been doing for the last 7 months? This thing has been in trials since April. And the technology behind it is far far older. How then is it confusing to you that they know what temps it can be stored at safely for 6 months?

No one whom hasn’t been subject to testing has had the vaccine.

Oh, and they’ve not tested it for 7 months.

Oh and this process is normally years long and many more variants of test recipients.

Bimbowomxn wrote: ↑Tue Nov 17, 2020 9:20 am


But blaming a Trump event and a Bikers event, I’m not so they’d have used a BLM protest....

Niegs wrote: ↑Tue Nov 17, 2020 12:01 pm

Bimbowomxn wrote: ↑Tue Nov 17, 2020 9:20 am


But blaming a Trump event and a Bikers event, I’m not so they’d have used a BLM protest....

If that was really your takeaway from that ... I completely missed any mention of mass-gathering events in that, but maybe it's because I was actually moved by a nurse seeing people die who don't believe they have what they have, largely because there are people turning a deadly virus into a political issue.

Niegs wrote: ↑Tue Nov 17, 2020 12:01 pm

Bimbowomxn wrote: ↑Tue Nov 17, 2020 9:20 am


But blaming a Trump event and a Bikers event, I’m not so they’d have used a BLM protest....

If that was really your takeaway from that ... I completely missed any mention of mass-gathering events in that, but maybe it's because I was actually moved by a nurse seeing people die who don't believe they have what they have, largely because there are people turning a deadly virus into a political issue.

Bimbowomxn wrote: ↑Tue Nov 17, 2020 11:44 am But

However

No

I’m not a contrarian

Insane_Homer wrote: ↑Tue Nov 17, 2020 12:28 pm Anyone else find it odd that all the rigorous questioning of evidence and science of a vaccine doesn't apply when it comes to evaluating the consequences of Brexit

Saint wrote: ↑Tue Nov 17, 2020 12:12 pm The biggest difference between this vaccine development schedule and a typical vaccine has been the very initial stages - precisely because new tech, whether the mRNA approach or the OXxford type - have enabled us to accurately produce a highly targeted functioning vaccine without the years of trial and error that has gone into the more traditional vaccine development programmes. After that, consolidating the Phase I/II and II/III has helped a lot, as has SCALE - a typical phase III programme would maybe have only 3,000 candidates, and therefore would take much longer for sufficient evidence of effectiveness to appear (it helps also that there's a LOT of Coronavirus around, so there's a high baseline to compare against)

Phase IV will continue post approval, but that's typical for most vaccines, as that involves long term study of immunity.

So, we short circuited the initial development cycle by years, but that merely got us to candidates. We've collapsed the testing programme by a year or 2 by running different phases at the same time, but the cumulative amount of time spent in testing is pretty much in line with other vaccines.

Raggs wrote: ↑Tue Nov 17, 2020 11:57 am

Bimbowomxn wrote: ↑Tue Nov 17, 2020 11:44 am

Not subject to testing? What do you think they've been doing for the last 7 months? This thing has been in trials since April. And the technology behind it is far far older. How then is it confusing to you that they know what temps it can be stored at safely for 6 months?

No one whom hasn’t been subject to testing has had the vaccine.

Oh, and they’ve not tested it for 7 months.

Oh and this process is normally years long and many more variants of test recipients.

You were asking how they can know that it can be safely stored for 6 months. Phase 1 trials started in April. We're in November 11-4 = 7. I suspect before they started phase 1 trials, they probably had some slight idea of how the fuck it was supposed to be stored so it doesn't degrade! And I guess they've probably had some stored for most of the duration of the trials. This has been tested for 7 months, and the stored for longer, since they'd have had to make the stuff before they could have started phase 1 trials anyway...

I need a better ignore function, one that doesn't show replies. My willpower has given up today and I keep opening the idiots comments.

Insane_Homer wrote: ↑Tue Nov 17, 2020 12:28 pm Anyone else find it odd that all the rigorous questioning of evidence and science of a vaccine doesn't apply when it comes to evaluating the consequences of Brexit

Saint wrote: ↑Tue Nov 17, 2020 12:12 pm The biggest difference between this vaccine development schedule and a typical vaccine has been the very initial stages - precisely because new tech, whether the mRNA approach or the OXxford type - have enabled us to accurately produce a highly targeted functioning vaccine without the years of trial and error that has gone into the more traditional vaccine development programmes. After that, consolidating the Phase I/II and II/III has helped a lot, as has SCALE - a typical phase III programme would maybe have only 3,000 candidates, and therefore would take much longer for sufficient evidence of effectiveness to appear (it helps also that there's a LOT of Coronavirus around, so there's a high baseline to compare against)

Phase IV will continue post approval, but that's typical for most vaccines, as that involves long term study of immunity.

So, we short circuited the initial development cycle by years, but that merely got us to candidates. We've collapsed the testing programme by a year or 2 by running different phases at the same time, but the cumulative amount of time spent in testing is pretty much in line with other vaccines.