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Re: So, coronavirus...

Posted: Wed Mar 17, 2021 2:37 am
by Enzedder
Hong Kong wrote: Wed Mar 17, 2021 1:09 am I’m getting the BioNTech vaccination: first on 31 March, 2nd on 21 April
Can I have your porn collection and bagpipes?

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 7:19 am
by Slick
Saint wrote: Tue Mar 16, 2021 6:46 pm
Slick wrote: Tue Mar 16, 2021 6:12 pm Is there any indication when we might be able to stay with family?
Looking at the unlock, it looks like possibly Phase III (May 17th), but that will need more detail closer to the time
Thanks, and Biffer. Getting a bit of pressure from my mum, who lives in England, to head down on the 26th April when we can move again. She will be fully vaccinated and says we can form a bubble

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 8:24 am
by Saint
Slick wrote: Wed Mar 17, 2021 7:19 am
Saint wrote: Tue Mar 16, 2021 6:46 pm
Slick wrote: Tue Mar 16, 2021 6:12 pm Is there any indication when we might be able to stay with family?
Looking at the unlock, it looks like possibly Phase III (May 17th), but that will need more detail closer to the time
Thanks, and Biffer. Getting a bit of pressure from my mum, who lives in England, to head down on the 26th April when we can move again. She will be fully vaccinated and says we can form a bubble
Bubble rules are different and provided you qualify you've been able to stay overnight through the whole lockdown

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 8:51 am
by TB63
Enzedder wrote: Wed Mar 17, 2021 2:37 am
Hong Kong wrote: Wed Mar 17, 2021 1:09 am I’m getting the BioNTech vaccination: first on 31 March, 2nd on 21 April
Can I have your porn collection?
You've not got enough time left on this earth to go through them all..

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 8:58 am
by Slick
Saint wrote: Wed Mar 17, 2021 8:24 am
Slick wrote: Wed Mar 17, 2021 7:19 am
Saint wrote: Tue Mar 16, 2021 6:46 pm

Looking at the unlock, it looks like possibly Phase III (May 17th), but that will need more detail closer to the time
Thanks, and Biffer. Getting a bit of pressure from my mum, who lives in England, to head down on the 26th April when we can move again. She will be fully vaccinated and says we can form a bubble
Bubble rules are different and provided you qualify you've been able to stay overnight through the whole lockdown
Yes, but with the travel restrictions it made it difficult to justify. My mum is currently in a bubble with my sister who lives locally but is intending to break that bubble before we go down and form it with us. All within rules as I read them, as long is there is sufficient time between bubbles. To be honest it's really difficult to say no now that she will be fully vaccinated even though we want to stick to the rules - I know it's not 100% protection.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 9:00 am
by Saint
Slick wrote: Wed Mar 17, 2021 8:58 am
Saint wrote: Wed Mar 17, 2021 8:24 am
Slick wrote: Wed Mar 17, 2021 7:19 am

Thanks, and Biffer. Getting a bit of pressure from my mum, who lives in England, to head down on the 26th April when we can move again. She will be fully vaccinated and says we can form a bubble
Bubble rules are different and provided you qualify you've been able to stay overnight through the whole lockdown
Yes, but with the travel restrictions it made it difficult to justify. My mum is currently in a bubble with my sister who lives locally but is intending to break that bubble before we go down and form it with us. All within rules as I read them, as long is there is sufficient time between bubbles. To be honest it's really difficult to say no now that she will be fully vaccinated even though we want to stick to the rules - I know it's not 100% protection.
Yeah, well in that case you're going to be legal. You need 2 weeks between one bubble ending and another starting, so as soon as you're allowed to cross the border then it's allowed

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 9:22 am
by Line6 HXFX
Had the vaccine yesterday.

Woke with back pain, neck pain, jaw pain, finger aches and a high temperature.

But hey, had the vaccine, super happy.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 9:27 am
by sturginho
Line6 HXFX wrote: Wed Mar 17, 2021 9:22 am Had the vaccine yesterday.

Woke with back pain, neck pain, jaw pain, finger aches and a high temperature.

But hey, had the vaccine, super happy.
Which one did you have?

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 9:28 am
by Slick
Line6 HXFX wrote: Wed Mar 17, 2021 9:22 am Had the vaccine yesterday.

Woke with back pain, neck pain, jaw pain, finger aches and a high temperature.

But hey, had the vaccine, super happy.
You've always been woke

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 10:35 am
by Saint
Sandstorm wrote: Tue Mar 16, 2021 11:30 am NHS now accepting requests for all over 50s. Login and pick your dates + location for 1st and 2nd jab today. No need to wait for your letter. :thumbup: :thumbup: :thumbup:

https://www.nhs.uk/conditions/coronavir ... ccination/

My wife booked her first jab for next Friday, then mid June.
They take a while, but finally got round to updating the front page

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 10:44 am
by Rinkals
Sandstorm wrote: Tue Mar 16, 2021 8:38 pm
Rinkals wrote: Tue Mar 16, 2021 7:59 pm
Sandstorm wrote: Tue Mar 16, 2021 3:35 pm I hope the EU keep delaying AZ rollout. Allow the UK time to vaccinate all our adults before Europeans get their head out of their arses.
I saw a figure (which I can't find: sorry), which suggested that, at the rate South Africans are currently getting the jab, it will be another twenty years before 60% of the population is inoculated.

So, I don't think you have to worry on that score: we should have bred enough resistant variants in that time to keep your hospitals busy in perpetuity.
Don’t be silly. Every country starts slowly and then ramps up the rollout.
First of all, I was being facetious. As I took you to be.

And secondly, I believe we are having difficulty securing supply of the vaccination.

Underlying my facetious remark was a serious point, namely that Nations that secure their own populations at the expense of poorer nations risk reinfection through the virus being allowed to thrive outside of their orbit.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 10:47 am
by Saint
Rinkals wrote: Wed Mar 17, 2021 10:44 am
Sandstorm wrote: Tue Mar 16, 2021 8:38 pm
Rinkals wrote: Tue Mar 16, 2021 7:59 pm

I saw a figure (which I can't find: sorry), which suggested that, at the rate South Africans are currently getting the jab, it will be another twenty years before 60% of the population is inoculated.

So, I don't think you have to worry on that score: we should have bred enough resistant variants in that time to keep your hospitals busy in perpetuity.
Don’t be silly. Every country starts slowly and then ramps up the rollout.
First of all, I was being facetious. As I took you to be.

And secondly, I believe we are having difficulty securing supply of the vaccination.

Underlying my facetious remark was a serious point, namely that Nations that secure their own populations at the expense of poorer nations risk reinfection through the virus being allowed to thrive outside of their orbit.
As mor vaccines are approved and more production comes on line, and more programmes are completed, more becomes available for all

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 10:48 am
by Raggs
Rinkals wrote: Wed Mar 17, 2021 10:44 am
Sandstorm wrote: Tue Mar 16, 2021 8:38 pm
Rinkals wrote: Tue Mar 16, 2021 7:59 pm

I saw a figure (which I can't find: sorry), which suggested that, at the rate South Africans are currently getting the jab, it will be another twenty years before 60% of the population is inoculated.

So, I don't think you have to worry on that score: we should have bred enough resistant variants in that time to keep your hospitals busy in perpetuity.
Don’t be silly. Every country starts slowly and then ramps up the rollout.
First of all, I was being facetious. As I took you to be.

And secondly, I believe we are having difficulty securing supply of the vaccination.

Underlying my facetious remark was a serious point, namely that Nations that secure their own populations at the expense of poorer nations risk reinfection through the virus being allowed to thrive outside of their orbit.
That's only a serious complaint once nations start to sit on stockpiles of vaccine, whilst others go without. As of now, no country has finished it's own vaccine program, and they mostly seem to be stabbing about as fast as they're getting (or close enough that the leftover is relative pocket change on a global scale). And it is in a country's benefit to vaccinate it's own population before others. A single jab can only vaccinate one person, whether it's in a rich or poor country.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 10:49 am
by Sandstorm
sturginho wrote: Wed Mar 17, 2021 9:27 am
Line6 HXFX wrote: Wed Mar 17, 2021 9:22 am Had the vaccine yesterday.

Woke with back pain, neck pain, jaw pain, finger aches and a high temperature.

But hey, had the vaccine, super happy.
Which one did you have?
Downtrodden one

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 11:48 am
by tabascoboy

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 11:58 am
by Rinkals
Saint wrote: Wed Mar 17, 2021 10:47 am
Rinkals wrote: Wed Mar 17, 2021 10:44 am
Sandstorm wrote: Tue Mar 16, 2021 8:38 pm

Don’t be silly. Every country starts slowly and then ramps up the rollout.
First of all, I was being facetious. As I took you to be.

And secondly, I believe we are having difficulty securing supply of the vaccination.

Underlying my facetious remark was a serious point, namely that Nations that secure their own populations at the expense of poorer nations risk reinfection through the virus being allowed to thrive outside of their orbit.
As mor vaccines are approved and more production comes on line, and more programmes are completed, more becomes available for all
There is currently a discussion on whether there might be a moratorium on IP restrictions on these vaccines to allow their production in India. South Africa, too, has a competent medical industry capable of producing medicines and vaccines, despite disparaging remarks made earlier on this thread.

However, without getting too Q-Anon, it is obviously in the drug companies' interests to prevent that from happening. Not only is there a strong imperative to defend their IP, but it obviously hurts the bottom line if treatment works too well. Sorry to sound a little conspiratorial, but these companies do not exist as entirely philanthropic entities.

That is probably neither here nor there, but the end result is probably going to be against opening up the IP.

But, to make my point again, if the virus is allowed to thrive in poorer countries, then it will probably resurface in wealthier nations in divers variants.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 12:50 pm
by Saint
Rinkals wrote: Wed Mar 17, 2021 11:58 am
Saint wrote: Wed Mar 17, 2021 10:47 am
Rinkals wrote: Wed Mar 17, 2021 10:44 am

First of all, I was being facetious. As I took you to be.

And secondly, I believe we are having difficulty securing supply of the vaccination.

Underlying my facetious remark was a serious point, namely that Nations that secure their own populations at the expense of poorer nations risk reinfection through the virus being allowed to thrive outside of their orbit.
As mor vaccines are approved and more production comes on line, and more programmes are completed, more becomes available for all
There is currently a discussion on whether there might be a moratorium on IP restrictions on these vaccines to allow their production in India. South Africa, too, has a competent medical industry capable of producing medicines and vaccines, despite disparaging remarks made earlier on this thread.

However, without getting too Q-Anon, it is obviously in the drug companies' interests to prevent that from happening. Not only is there a strong imperative to defend their IP, but it obviously hurts the bottom line if treatment works too well. Sorry to sound a little conspiratorial, but these companies do not exist as entirely philanthropic entities.

That is probably neither here nor there, but the end result is probably going to be against opening up the IP.

But, to make my point again, if the virus is allowed to thrive in poorer countries, then it will probably resurface in wealthier nations in divers variants.
It's far from clear how much capacity there actually is, particularly if we intend to keep up manufacturing cpacity for all those other pesky viruses like Smallpox. Additionally, few few of these vaccines are actually manufactured in a single facility - the supply chains are complex with many limiting factors. For instance even if you could spin up a final production facility for Pfizer in SA, there's a core component to it that is currently only manufactured in 2 factories in the world, and I've seen estimates that it could take between 6 and 18 months to bring any other facility on line.

As much as anything, this is why it's important to have many vaccines of different types so as to best utilise what manufacturing capacity we have

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 12:54 pm
by JM2K6
The defence force out on TV today:



Ah yes, no-one could possibly have known the virus was deadly or that Boris was being irresponsible, it is only with the benefit of hindsight and not, you know, HAVING LOOKED AT CHINA AND ITALY AND HAVING A FUCKING HEAD START ON EVERYONE ELSE AND BLINDLY REFUSING TO PAY ATTENTION

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 12:54 pm
by Calculon
Rinkals wrote: Wed Mar 17, 2021 11:58 am
Saint wrote: Wed Mar 17, 2021 10:47 am
Rinkals wrote: Wed Mar 17, 2021 10:44 am

First of all, I was being facetious. As I took you to be.

And secondly, I believe we are having difficulty securing supply of the vaccination.

Underlying my facetious remark was a serious point, namely that Nations that secure their own populations at the expense of poorer nations risk reinfection through the virus being allowed to thrive outside of their orbit.
As mor vaccines are approved and more production comes on line, and more programmes are completed, more becomes available for all
There is currently a discussion on whether there might be a moratorium on IP restrictions on these vaccines to allow their production in India. South Africa, too, has a competent medical industry capable of producing medicines and vaccines, despite disparaging remarks made earlier on this thread.

However, without getting too Q-Anon, it is obviously in the drug companies' interests to prevent that from happening. Not only is there a strong imperative to defend their IP, but it obviously hurts the bottom line if treatment works too well. Sorry to sound a little conspiratorial, but these companies do not exist as entirely philanthropic entities.

That is probably neither here nor there, but the end result is probably going to be against opening up the IP.

But, to make my point again, if the virus is allowed to thrive in poorer countries, then it will probably resurface in wealthier nations in divers variants.
All valid points but South Africa would have a stronger argument if they didn't turn away 1.5 million AZ vaccine despite WHO recommendations not to do so. I believe this is the first time the SA government has gone against WHO advice and as I've stated previously, I think it is a terrible case of CYA, principly by the scientists in the Ministerial Advisory Committee on COVID-19, and secondly by the politicians that don't have the balls to overrule their scientific advisors.
- all because of the remote chance that the AZ will prove ineffective against severe disease caused by covsars 2- SA varient, and thus people will have to be vaccinated twice. The SA government was also late in starting to procure vaccines even as it became clear that those vaccines will be effective.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 12:54 pm
by Rinkals
^^^

Nobody claimed that the SA Government was logical

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 12:59 pm
by Rinkals
Saint wrote: Wed Mar 17, 2021 12:50 pm It's far from clear how much capacity there actually is, particularly if we intend to keep up manufacturing cpacity for all those other pesky viruses like Smallpox. Additionally, few few of these vaccines are actually manufactured in a single facility - the supply chains are complex with many limiting factors. For instance even if you could spin up a final production facility for Pfizer in SA, there's a core component to it that is currently only manufactured in 2 factories in the world, and I've seen estimates that it could take between 6 and 18 months to bring any other facility on line.

As much as anything, this is why it's important to have many vaccines of different types so as to best utilise what manufacturing capacity we have
In which case, why the reticence in offering a limited moratorium on the IP involved?

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 1:03 pm
by Saint
Rinkals wrote: Wed Mar 17, 2021 12:59 pm
Saint wrote: Wed Mar 17, 2021 12:50 pm It's far from clear how much capacity there actually is, particularly if we intend to keep up manufacturing cpacity for all those other pesky viruses like Smallpox. Additionally, few few of these vaccines are actually manufactured in a single facility - the supply chains are complex with many limiting factors. For instance even if you could spin up a final production facility for Pfizer in SA, there's a core component to it that is currently only manufactured in 2 factories in the world, and I've seen estimates that it could take between 6 and 18 months to bring any other facility on line.

As much as anything, this is why it's important to have many vaccines of different types so as to best utilise what manufacturing capacity we have
In which case, why the reticence in offering a limited moratorium on the IP involved?
Because while the USE of the IP can be limited for this specific vaccine, the actual knowledge shared won't be forgotten - which in turn could have serious commercial impact somewhere down the road on a different project. Whilst for a more traditional vaccine that's probably not an issue as everyone more or less knows how to develop and produce them, for the newer platforms there's a huge amount of investment in the general technology and development that the various companies need to protect

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 1:07 pm
by Rinkals
In other words, it's more important to make profits than to save lives.

I understand perfectly.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 1:17 pm
by Saint
Rinkals wrote: Wed Mar 17, 2021 1:07 pm In other words, it's more important to make profits than to save lives.

I understand perfectly.
I'm of two minds to this, but actually it's the long term ability of Pharma to make profits that enables their long term ability to develop new vaccines and technologies.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 1:42 pm
by Lobby
I see Ursula is back on the warpath




Re: So, coronavirus...

Posted: Wed Mar 17, 2021 1:46 pm
by Raggs
We're going to stop others having vaccines whilst simultaneously not using all the vaccines we have! Well done them...

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 1:51 pm
by Saint
Great. Time for a bit more posturing. It can;t really go anywhere as a core Pfizer component is manufactured in the UK, and no-one really wants this to get that ugly

I'm curious as to what Ursula means about recieving exports from the USA though, when the USA has a blanket ban on any exports of any Covid vaccine, whether it's certified for use in the USA or not (see 70million odd doses of AZ sitting in warehouses)

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 2:09 pm
by Lobby
Saint wrote: Wed Mar 17, 2021 1:51 pm Great. Time for a bit more posturing. It can;t really go anywhere as a core Pfizer component is manufactured in the UK, and no-one really wants this to get that ugly

I'm curious as to what Ursula means about recieving exports from the USA though, when the USA has a blanket ban on any exports of any Covid vaccine, whether it's certified for use in the USA or not (see 70million odd doses of AZ sitting in warehouses)
I think she means that there is reciprocity with the US because no EU manufactured vaccines have gone to the US; hence the US ban doesn’t affect the EU (despite there being a surfeit of unused AZ vaccines in the US).

As the UK has received 9m Pfizer vaccines from EU plants, in line with our contracts, she thinks we should reciprocate and provide the EU with AZ vaccines, despite the lack of any contractual basis for us doing so.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 2:10 pm
by tc27
The Commissions decision to prioritise price over speed of delivery was bad enough but its the various cack handed attempts to try and placate amd distract from the consequences that are far worse.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 2:11 pm
by tc27
PS 530k vaccinations given yesterday.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 2:23 pm
by Dinsdale Piranha
Saint wrote: Wed Mar 17, 2021 1:17 pm
Rinkals wrote: Wed Mar 17, 2021 1:07 pm In other words, it's more important to make profits than to save lives.

I understand perfectly.
I'm of two minds to this, but actually it's the long term ability of Pharma to make profits that enables their long term ability to develop new vaccines and technologies.
Basically, yes. Developing drugs is expensive and time consuming. If at any one time a phama company has one blockbuster drug, that's a massive result. I spent several years selling computers to pharma companies and met a fair few of their R&D people. The timescale for making money off them is limited. I was dealing with Eli Lilly when Prozac went off patent. They decided to see if they could slow the adoption of generics through advertising etc. End result - fastest ever shift to generics :lol:

Vaccines tend not to be massively profitable and are designed to eliminate the condition they target - this is why most of the original research has to be publicly funded. One of the interesting things about COVID is to see how quickly you can move when everybody has a vested interest in success.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 2:29 pm
by Sandstorm
Whooo hooo! Got a call just now, going in on Friday for 1st jab. :clap:

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 2:40 pm
by Dinsdale Piranha
tc27 wrote: Wed Mar 17, 2021 2:11 pm PS 530k vaccinations given yesterday.
That's over 1/4 up on the highest Tuesday number so far.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 3:18 pm
by Saint
Lobby wrote: Wed Mar 17, 2021 2:09 pm
Saint wrote: Wed Mar 17, 2021 1:51 pm Great. Time for a bit more posturing. It can;t really go anywhere as a core Pfizer component is manufactured in the UK, and no-one really wants this to get that ugly

I'm curious as to what Ursula means about recieving exports from the USA though, when the USA has a blanket ban on any exports of any Covid vaccine, whether it's certified for use in the USA or not (see 70million odd doses of AZ sitting in warehouses)
I think she means that there is reciprocity with the US because no EU manufactured vaccines have gone to the US; hence the US ban doesn’t affect the EU (despite there being a surfeit of unused AZ vaccines in the US).

As the UK has received 9m Pfizer vaccines from EU plants, in line with our contracts, she thinks we should reciprocate and provide the EU with AZ vaccines, despite the lack of any contractual basis for us doing so.
OK. More posturing, paint the UK as the bad guy, cover for her own mistakes etc. It's just frustrating that so much time and effort is being spent on this type of thing when it could be used far more profitably.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 3:47 pm
by Rinkals
Saint wrote: Wed Mar 17, 2021 1:17 pm
Rinkals wrote: Wed Mar 17, 2021 1:07 pm In other words, it's more important to make profits than to save lives.

I understand perfectly.
I'm of two minds to this, but actually it's the long term ability of Pharma to make profits that enables their long term ability to develop new vaccines and technologies.
Actually, I do understand their concerns.

But to my mind, it risks allowing the virus to incubate with the possibility of nastier versions down the line.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 3:58 pm
by Saint
Rinkals wrote: Wed Mar 17, 2021 3:47 pm
Saint wrote: Wed Mar 17, 2021 1:17 pm
Rinkals wrote: Wed Mar 17, 2021 1:07 pm In other words, it's more important to make profits than to save lives.

I understand perfectly.
I'm of two minds to this, but actually it's the long term ability of Pharma to make profits that enables their long term ability to develop new vaccines and technologies.
Actually, I do understand their concerns.

But to my mind, it risks allowing the virus to incubate with the possibility of nastier versions down the line.
But it also risks a complete lack of investment and development in future tech to deal with the next big outbreak. There aren't any good answers here at all

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 4:02 pm
by Saint
In other news - final Novovax Phase III results are in. 96% effective in preventing infections for the original strain, 86% against the "Kent" variant. 100% effective in preventing death from either strain.

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 4:05 pm
by Lemoentjie
Lobby wrote: Wed Mar 17, 2021 1:42 pm I see Ursula is back on the warpath
Why does she have a random leaf pinned to her shirt?

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 4:08 pm
by Raggs
Saint wrote: Wed Mar 17, 2021 4:02 pm In other news - final Novovax Phase III results are in. 96% effective in preventing infections for the original strain, 86% against the "Kent" variant. 100% effective in preventing death from either strain.
So on the assumption that they've been reviewing results in real time, and not just waiting on the final results to publish, we've got a week or so before this gets full approval?

Re: So, coronavirus...

Posted: Wed Mar 17, 2021 4:15 pm
by Saint
Raggs wrote: Wed Mar 17, 2021 4:08 pm
Saint wrote: Wed Mar 17, 2021 4:02 pm In other news - final Novovax Phase III results are in. 96% effective in preventing infections for the original strain, 86% against the "Kent" variant. 100% effective in preventing death from either strain.
So on the assumption that they've been reviewing results in real time, and not just waiting on the final results to publish, we've got a week or so before this gets full approval?
They;ve been on a rolling review for some time. I think Novovax still have to submit some manufacturing data to MHRA, but the emergency approval has to be imminent